The treatment of steroid sensitive nephrotic syndrome

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Steroid Sensitive Nephrotic Syndrome in Children

Nephrotic Syndrome (NS) is one of the most frequent glomerular diseases seen in children. Children who go into complete remissin following treatment with corticosteroids are classified as having “steroid sensitive” NS. In developed countries over 80% of children with idiopathic NS have steroid sensitive disease although response to steroids is somewhat tempered in developing countries, especial...

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Disease course in steroid sensitive nephrotic syndrome.

OBJECTIVE To review the disease course in patients with steroid sensitive nephrotic syndrome (SSNS) and the factors that determine outcome DESIGN Retrospective, analytical SETTING Pediatric Nephrology Clinic at referral center in North India PARTICIPANTS/PATIENTS All patients with SSNS evaluated between 1990 and 2005 INTERVENTION: None MAIN OUTCOME MEASURES Disease course, in patients w...

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Relapse in Steroid-sensitive Nephrotic Syndrome

The objective of this study was to identify predictors of relapse and determine the predictive score for relapse in steroid-sensitive nephrotic syndrome. Ninety-nine children with nephrotic syndrome visiting the pediatric nephrology outpatient clinic of Soetomo Hospital from 1983 to 2001 were studied. There were 63 children with relapses (50 infrequent relapses, 13 frequent relapses) and 36 chi...

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Treatment of steroid-resistant pediatric nephrotic syndrome

Children who suffer from steroid-resistant nephrotic syndrome (SRNS) require aggressive treatment to achieve remission. When intravenous high-dose methylprednisolone fails, calcineurin inhibitors, such as cyclosporine and tacrolimus, are used as the first line of treatment. A significant number of patients with SRNS progress to end-stage renal disease if remission is not achieved. For these chi...

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Treatment of steroid-resistant nephrotic syndrome.

Nephrotic syndrome is the most common glomerular disorder in children, and corticosteroids are the first choice of treatment. While the majority of children respond to corticosteroid therapy, a few do not enter remission after daily therapy for 1-2 months, hence showing steroid-resistance. Most of these children show focal and segmental glomerulosclerosis (FSGS) upon renal biopsy. Steroid resis...

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ژورنال

عنوان ژورنال: Sri Lanka Journal of Child Health

سال: 2009

ISSN: 2386-110X,1391-5452

DOI: 10.4038/sljch.v31i1.800